Protein Synthesis upon Acute Nutrient Restriction Relies on Proteasome Function
نویسندگان
چکیده
منابع مشابه
Protein synthesis upon acute nutrient restriction relies on proteasome function.
The mechanisms that protect mammalian cells against amino acid deprivation are only partially understood. We found that during an acute decrease in external amino acid supply, before up-regulation of the autophagosomal-lysosomal pathway, efficient translation was ensured by proteasomal protein degradation. Amino acids for the synthesis of new proteins were supplied by the degradation of preexis...
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ژورنال
عنوان ژورنال: Science
سال: 2005
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.1121925